Zhang LP, Nie Q, Kang JB, Wang B, Cai CL, Li JG, Qi WJ.

Department of Radiation Oncology, Naval General Hospital of PLA, Beijing 100037, PR China. drwangbin@hotmail.com .

BACKGROUND & OBJECTIVE: Radiotherapy and chemotherapy are major therapies for locally advanced pancreatic cancer. This study was to Evaluate the efficacy of three-dimensional conformal radiotherapy combined gamma knife with heat chemotherapy on locally advanced pancreatic cancer.

METHODS: From December 2001 to January 2006, 75 patients with locally advanced pancreatic cancer Were Divided Into Group radiotherapy (37 patients) and combination group (38 patients). All Patients Received gamma knife stereotactic radiotherapy using Gamma Ray Radiotherapy System, with iso-dose curves of 50% -60%, tumor encircling dose or 3.0-4.5 Gy per fraction, fraction 8-11. The patient in combination therapy group at 41.5-43.5 Received simultaneous thermal Celsius (1 h / fraction, Twice a week for 6 times), and chemotherapy with venous administration of tegafur (0.5-1.0 g) and calcium folinate (CF, 0.2 g) for 4-6 times, or venous administration of gemcitabine (0.6-1.0 g / m (2)) on Days 1 and 8 and cisplatin (DDP) (20-30 mg / m (2)) on Days 1-3, repeated everytime 28 days for 3-6 cycles.

RESULTS: At 3 months after treatment, the overall response (complete remission and partial remission) rate was 70.7% (53/75), the response rate was 73.7% in the combination group and 67.5% in radiotherapy group. The 1-year survival rate was 48.3%, and the 2-year survival rate was 22.1%. The 1-and 2-year survival rates 51.2% and 26.5% Were in the combination group, and 45.2% and 17.6% in radiotherapy group. Complications No serious, suche as perforation, bleeding and high fever, Were seen consistently treatment and follow-up.

CONCLUSION: 3-D conformal radiotherapy gamma knife combined with thermo-chemotherapy was well tolerated and has relatively Effective for Patients with locally advanced pancreatic must cancer.