Immature dendritic cells Enhance antitumor effects
or hyperthermia

Reuters Health

NEW YORK (Reuters Health) - Injection of immature dendritic cells Writing Treated tumors with hyperthermia enhances the antitumor effect, According To a report in the September 10th issue of the International Journal of Cancer.

That previous research HAS shown hyperthermia induces antitumor immunity related to expression of heat shock proteins, dendritic cells activate Which Also, the authors explain.

Dr. Hiroyuki Honda, from Nagoya University in Japan, and colleagues investigated the feasibility of a novel therapy combining hyperthermia with Magnetite cationic liposomes (to foster intracellular heating) and intratumoral injection of immature dendritic cells for malignant melanoma in a mouse model.
Immature dendritic cells pulsed v in vitro with tumor cells heated Increased Surface Expression of Various molecules, "including the chemokine receptor CCR7, the authors report, Indicating That heated tumor cells dendritic cell maturation Can induction.

Treated mice with melanoma tumors continued to grow progressively hyperthermia, the results Indicating, but 2 or 10 with immature dendritic Similar Treated mice showed suppression of tumor cell growth.

Combination of hyperthermia with immature dendritic cell injection suppressed tumor growth, the researchers note, that result in complete regression or 6 or 10 subcutaneous tumors.

Survival was prolonged by dendritic cell Slightly treatment alone, the researchers note, but combination treatment with hyperthermia and immature dendritic cell injection significantly prolonged survival (p 0.05).

Combination therapy induced cytotoxic T lymphocytes and bone healing natural killer cells, the report INDICATIONS, and all mice exhibit complete regression of melanoma tumor cells injected tumors Rejected subsequently.

"These results suggestive That our system hyperthermia induced a vaccine-like effect caused by necrotic cell death by heat shock protein 70 expression and in vivo combination with immature dendritic ITS That was a potent cell therapeutic methodology," the investigators concluding.

"Based on thesis results," the authors add, "We Believe That combination therapy using hyperthermia, or Magnetite cationic liposomes and intratumoral injection of immature dendritic cells is Applicable to Patients with advanced malignancies as a novel cancer therapy."

Int J. Cancer 2005, 116:624-633.